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Sjögren's Syndrome Sjögren's ("SHOW-grins") syndrome is a chronic disease in which white blood cells attack the moisture-producing glands. The hallmark symptoms are dry eyes and dry mouth, but it is a systemic disease, affecting many organs and may cause fatigue. It is one of the most prevalent autoimmune disorders, striking as many as four million Americans. For more on the oral implications of Sjögren's syndrome, check out the following articles from the Sjögren's Syndrome Foundation:
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