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Further standardization difficulties arise when attempts are made to quantify a subjects assessment of a change in pain sensation. Pain is a subjective phenomenon which defies objective measurement. Most clinical trials have employed either the Verbal Rating Scale (VRS) or the Visual Analog Scale (VAS). A VRS may have three to five descriptors that allow a person to verbally grade the degree of discomfort. The VAS approach provides a line, usually 10 cm in length, that represents a continuum from no pain to severe pain. Subjects place a mark at the location that best indicates their level of discomfort. The VAS has generally been found to be more reproducible, and therefore, more appropriate for hypersensitivity measurement than the VRS.15 However, both approaches rely on an individuals subjective assessment of change in the intensity of pain. Examples of a VAS and VRS are shown in Table I. |
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ŠADHA
2003
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