Antimicrobials -1
Antimicrobial therapy is an important adjunct in managing the oral complications of xerostomia, and is used to reduce plaque formation, and to prevent or reduce the severity of gingivitis. Regular use of antimicrobials promotes a healthy oral ecosystem, and maintains a balance in the oral flora. There are a variety of available OTC and prescription antimicrobials from which to choose.
Saliva itself is antibacterial, by altering bacteria through complex actions of salivary enzymes and proteins. They may either kill bacteria directly, or interfere with cell growth and replication. The salivary enzyme lactoferrin is bacteriostatic, and kills both aerobic and facultative bacteria by binding iron necessary for bacterial growth. Salivary Iysozyme causes bacterial cell Iysis by binding to the cell wall. Another enzyme, lactoperoxidase, converts the hydrogen peroxide produced by bacteria to hypocyanite, a highly reactive oxidizing agent that effects bacterial acid production and growth. Lactoferrin, Iysozyme and lactoperoxidase are all extremely effective against Streptococcus mutans.37, 38, 39, 40 Biotene® oral care products, including Biotene® alcohol free mouth rinse, contain these key enzymes found in natural saliva, and with regular use, simulate salivary antibacterial properties.
